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A third-generation cephalosporin Nursing Management the nurse caring for any patient in any setting must keep in mind the risks of sepsis and the high mortality rate associated with septic shock fungi definition pronunciation generic ketoconazole 200mg line. All invasive procedures must be carried out with aseptic technique after careful hand hygiene anti yeast underwear generic ketoconazole 200 mg online. Additionally fungus ball discount ketoconazole online american express, intravenous lines fungus gnats lawn order ketoconazole no prescription, arterial and venous puncture sites, surgical incisions, traumatic wounds, urinary catheters, and pressure ulcers are monitored for signs of infection in all patients. The nurse identifies patients at particular risk for sepsis and septic shock (ie, elderly and immunosuppressed patients or patients with extensive trauma or burns or diabetes), keeping in mind that these high-risk patients may not develop typical or classic signs of infection and sepsis. Confusion, for example, may be the first sign of infection and sepsis in elderly patients. When caring for the patient with septic shock, the nurse collaborates with other members of the health care team to identify the site and source of sepsis and the specific organisms involved. Appropriate specimens for culture and sensitivity are often obtained by the nurse. Thus, an elevated temperature may not be treated unless it reaches dangerous levels (more than 40°C [104°F]) or unless the patient is uncomfortable. Efforts may be made to reduce the temperature by administering acetaminophen or applying hypothermia blankets. During these therapies, the nurse monitors the patient closely for shivering, which increases oxygen consumption. Efforts to increase comfort are important if the patient experiences fever, chills, or shivering. The nurse administers prescribed intravenous fluids and medications, including antibiotic agents and vasoactive medications to restore vascular volume. Because of decreased perfusion to the kidneys and liver, serum concentrations of antibiotic agents that are normally cleared by these organs may increase and produce toxic effects. If the patient complains of pain in the calf, the sign is positive and suggestive of deep vein thrombosis. Administering heparin or low-molecular-weight heparin (Lovenox) as prescribed, applying elastic compression stockings, or initiating pneumatic compression of the legs may prevent thrombus formation. Performing passive range of motion of the immobile extremities helps promote circulation. Patients who have experienced a spinal cord injury may not report pain caused by internal injuries. Therefore, in the immediate postinjury period, the nurse must monitor the patient closely for signs of internal bleeding that could lead to hypovolemic shock. This process requires that the patient has previously been exposed to the substance. An antigenantibody reaction provokes mast cells to release potent vasoactive substances, such as histamine or bradykinin, that cause widespread vasodilation and capillary permeability. Because anaphylactic shock occurs in patients already exposed to an antigen who have developed antibodies to it, it can often be prevented. Therefore, patients with known allergies need to understand the consequences of subsequent exposure to the antigen and should wear medical identification that lists their sensitivities. This could prevent inadvertent administration of a medication that would lead to anaphylactic shock. Additionally, the patient and family need instruction about emergency use of medications to treat anaphylaxis. This can be caused by spinal cord injury, spinal anesthesia, or nervous system damage. It can also result from the depressant action of medications or lack of glucose (eg, insulin reaction or shock). Neurogenic shock may have a prolonged course (spinal cord injury) or a short one (syncope or fainting). It is characterized by dry, warm skin rather than the cool, moist skin seen in hypovolemic shock. Another characteristic is bradycardia, rather than the tachycardia that characterizes other forms of shock.
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Pathophysiology the underlying pathology in asthma is reversible and diffuse airway inflammation antifungal liquid drops cheap 200 mg ketoconazole overnight delivery. The inflammation leads to obstruction from the following: swelling of the membranes that line the airways (mucosal edema) fungus gnats in hydro purchase generic ketoconazole on-line, reducing the airway diameter; contraction of the bronchial smooth muscle that encircles the airways (bronchospasm) fungus gnats peroxide purchase 200mg ketoconazole free shipping, causing further narrowing; and increased mucus production antifungal grass treatment for lawn discount ketoconazole american express, which diminishes airway size and may entirely plug the bronchi. The bronchial muscles and mucus glands enlarge; thick, tenacious sputum is produced; and the alveoli hyperinflate. This is called airway "remodeling" and occurs in response to chronic inflammation. Cells that play a key role in the inflammation of asthma are mast cells, neutrophils, eosinophils, and lymphocytes. Regulation of these chemicals is the aim of much of the current research regarding pharmacologic therapy for asthma. Further, alpha- and beta2-adrenergic receptors of the sympathetic nervous system are located in the bronchi. When the alphaadrenergic receptors are stimulated, bronchoconstriction occurs; when the beta2-adrenergic receptors are stimulated, bronchodila- tion results. Clinical Manifestations the three most common symptoms of asthma are cough, dyspnea, and wheezing. Asthma attacks often occur at night or early in the morning, possibly due to circadian variations that influence airway receptor thresholds. An asthma exacerbation may begin abruptly but most frequently is preceded by increasing symptoms over the previous few days. At times the mucus is so tightly wedged in the narrowed airway that the patient cannot cough it up. There may be generalized wheezing (the sound of airflow through narrowed airways), first on expiration and then possibly during inspiration as well. As the exacerbation progresses, diaphoresis, tachycardia, and a widened pulse pressure may occur along with hypoxemia and central cyanosis (a late sign of poor oxygenation). Although life-threatening and severe hypoxemia can occur in asthma, it is relatively uncommon. The hypoxemia is secondary to a ventilationperfusion mismatch and readily responds to supplemental oxygenation. Chapter 24 Management of Patients With Chronic Obstructive Pulmonary Disease 589 Symptoms of exercise-induced asthma include maximal symptoms during exercise, absence of nocturnal symptoms, and sometimes only a description of a "choking" sensation during exercise. While 83% of physicians reported prescribing peak flow meter monitoring, only 62% of patients had ever heard of a peak flow meter (Rickard & Stempel, 1999). Complications Assessment and Diagnostic Findings A complete family, environmental, and occupational history is essential. To establish the diagnosis, the clinician must determine that periodic symptoms of airflow obstruction are present, airflow is at least partially reversible, and other etiologies have been excluded. A positive family history and environmental factors, including seasonal changes, high pollen counts, mold, climate changes (particularly cold air), and air pollution, are primarily associated with asthma. In addition, asthma is associated with a variety of occupation-related chemicals and compounds, including metal salts, wood and vegetable dust, medications (eg, aspirin, antibiotics, piperazine, cimetidine), industrial chemicals and plastics, biologic enzymes (eg, laundry detergents), animal and insect dusts, sera, and secretions. Comorbid conditions that may accompany asthma include gastroesophageal reflux, drug-induced asthma, and allergic bronchopulmonary aspergillosis. Other possible allergic reactions that may accompany asthma include eczema, rashes, and temporary edema. During acute episodes, sputum and blood tests may disclose eosinophilia (elevated levels of eosinophils). Arterial blood gas analysis and pulse oximetry reveal hypoxemia during acute attacks. The occurrence of a severe, continuous reaction is referred to as status asthmaticus and is considered life-threatening (see below). Complications of asthma may include status asthmaticus, respiratory failure, pneumonia, and atelectasis. Airway obstruction, particularly during acute asthmatic episodes, often results in hypoxemia, requiring the administration of oxygen and the monitoring of pulse oximetry and arterial blood gases. Fluids are administered because people with asthma are frequently dehydrated from diaphoresis and insensible fluid loss with hyperventilation.
This course also reflects a downward trend with progressive debilitation and eventual death fungus cream buy 200 mg ketoconazole overnight delivery. The third pattern is a clear downward slope with many physiologic parameters indicating that death is imminent fungus gnats larvae jump order discount ketoconazole on-line. This pattern is often observed in the critical care unit when people and families have no time to prepare for the death fungus yellow mulch cheap ketoconazole american express. The last pattern is a downward slant that reveals a crisis event fungus in nails order ketoconazole 200 mg fast delivery, such as a severe cerebral hemorrhage with almost no hope of recovery. The nurse should recognize that a person may experience one or more of these livingdying patterns. The nurse must also be concerned with ethical considerations and quality-of-life issues that affect dying people. Of utmost importance to the patient is assistance with the transition from living to dying, maintaining and sustaining relationships, finishing well with the family, and accomplishing what needs to be said and done. Retaining as much control as possible during the process of dying allows the patient and family to make as much sense as possible out of an overwhelming situation. In the hospital, in long-term care facilities, and in home settings, the nurse explores choices and end-of-life decisions with the patient and family. Referrals to home care and hospice services, as well as specific referrals appropriate for the management of the situation, are initiated. The use of living wills and advance directives allows the patient to exercise the right to have a "good" death or to die with dignity. Spirituality and Spiritual Distress Spirituality is defined as connectedness with self, others, a life force, or God that allows people to experience self-transcendence and find meaning in life. Spirituality helps people discover a purpose in life, understand the vicissitudes of life, and develop their relationship with God or a Higher Power. Within the framework of spirituality, a person discovers truths about the self, about the world, and about concepts such as love, compassion, wisdom, honesty, commitment, imagination, reverence, and morality. Often, spiritual behavior is expressed through sacrifice, self-discipline, and spending time in activities that focus on the inner self or the soul. Religion and nature are two vehicles that people use to connect themselves with God or a Higher Power; however, bonds to religious institutions, beliefs, or dogma are not required to experience the spiritual sense of self. Faith, considered the foundation of spirituality, is a belief in something that a person cannot see (Carson, 1999). The spiritual part of a person views life as a mystery that unfolds over the lifetime, encompassing questions about meaning, hope, relatedness to God, acceptance or forgiveness, and transcendence (Byrd, 1999; Sheldon, 2000; Sussman, Nezami, & Mishra, 1997). A strong sense of spirituality or religious faith can have a positive impact on health (Dunn & Horgas, 2000; Kendrick & Robinson, 2000; Matthews & Larson, 1995). Spirituality is also a component of hope, and, especially during chronic, serious, or terminal illness, patients and their families often find comfort and emotional strength in their religious traditions or spiritual beliefs. At other times, illness and loss can cause a loss of faith or meaning in life and a spiritual crisis. The nursing diagnosis of spiritual distress is applicable to those who have a disturbance in the belief or value system that provides strength, hope, and meaning in life. Interpersonal relationships: Professional communication skills for nurses (3rd ed. The faith factor: An annotated bibliography of clinical research on spiritual subjects (Vol. Handbook of stress, coping, and health: Implications for nursing research, theory, and practice. Clinical practice guidelines Agency for Health Care Policy and Research: Number 5. For nurses to provide spiritual care, they must be open to being present and supportive when patients experience doubt, fearfulness, suffering, despair, or other difficult psychological states of being. Interventions that foster spiritual growth or reconciliation include being fully present; listening actively; conveying a sense of caring, respect, and acceptance; using therapeutic communication techniques to encourage expression; suggesting the use of prayer, meditation, or imagery; and facilitating contact with spiritual leaders or performance of spiritual rituals (Sumner, 1998; Sussman, 2000). Patients with serious, chronic, or terminal illnesses face physical and emotional losses that threaten their spiritual integrity. During acute and chronic illness, rehabilitation, or the dying process, spiritual support can stimulate patients to regain or strengthen their connections with their inner selves, their loved ones, and their God or Higher Power to transcend suffering and find meaning. Critical Thinking Exercises A 55-year old man tells the nurse that he is not going to be a part of a clinical drug investigation.
Evaluation of serum electrolytes is indicated to identify any decrease in potassium as hydrogen is pulled out of the cells in exchange for potassium; decreased calcium antifungal treatment for scalp order ketoconazole 200 mg overnight delivery, as severe alkalosis inhibits calcium ionization fungus gnats outside order ketoconazole discount, resulting in carpopedal spasms and tetany; or decreased phosphate due to alkalosis fungus dog vomit purchase 200mg ketoconazole free shipping, causing an increased uptake of phosphate by the cells antifungal and antibacterial shampoo discount ketoconazole 200mg without prescription. Patients with chronic respiratory alkalosis are usually asymptomatic, and the diagnostic evaluation and plan of care are the same as for acute respiratory alkalosis. The analysis is usually based on an arterial blood sample, but when an arterial sample cannot be obtained, a mixed venous sample may be used. Results of arterial blood gas analysis provide information about alveolar ventilation, oxygenation, and acidbase balance. It is necessary to evaluate the serum electrolytes (sodium, potassium, and chloride) and carbon dioxide along with arterial blood gas data as they are often the first sign of an acidbase disorder. The health history, physical examination, previous blood gas results, and serum electrolytes should always be part of the assessment used to determine the cause of the acidbase disorder (Kraut & Madias, 2001). Medical Management Treatment depends on the underlying cause of respiratory alkalosis (Foster et al. Treatment for other causes of respiratory alkalosis is directed at correcting the underlying problem. Electrolyte solutions are considered isotonic if the total electrolyte content (anions + cations) is approximately 310 mEq/L. They are considered hypotonic if the total electrolyte content is less than 250 mEq/L and hypertonic if the total electrolyte content exceeds 375 mEq/L. For example, a 10% dextrose solution has an osmolality of approximately 505 mOsm/L. Bicarbonate is the basic or alkaline side of the "carbonic acidbicarbonate buffer system. If it is moving in the same direction as the primary value, compensation is underway. Arterial Blood Gases the following steps are recommended to evaluate arterial blood gas values. A compensated imbalance is one in which the body has been able to correct the pH by either respiratory or metabolic changes (depending on the primary problem). If the compensatory mechanism is able to restore the bicarbonate to carbonic acid ratio back to 20:1, full compensation (and thus normal pH) will be achieved. The dextrose is quickly metabolized, however, and only the isotonic solution remains. Similarly, with hypotonic multipleelectrolyte solutions containing 5% dextrose, once the dextrose is metabolized, these solutions disperse as hypotonic fluids. Higher concentrations of dextrose, such as 50% dextrose in water, are administered to help meet caloric requirements. These solutions are strongly hypertonic and must be administered into central veins so that they can be diluted by rapid blood flow. If administered rapidly or in large quantity, they may cause an extracellular volume excess and precipitate circulatory overload and dehydration. As a result, these solutions must be administered cautiously and usually only when the serum osmolality has decreased to dangerously low levels. For the same reason, 3 L of isotonic fluid is needed to replace 1 L of blood loss. Because these fluids expand the intravascular space, patients with hypertension and heart failure should be carefully monitored for signs of fluid overload. Once administered, the glucose is rapidly metabolized, and this initially isotonic solution then disperses as a hypotonic fluid, one-third extracellular and two-thirds intracellular. It is essential to consider this action of D5W, especially if the patient is at risk for increased intracranial pressure. During fluid resuscitation, this solution should not be used because it can cause hyperglycemia. Therefore, D5W is used mainly to supply water and to correct an increased serum osmolality. For this reason, normal saline solution is often used to correct an extracellular volume deficit. It is used with administration of blood transfusions and to replace large sodium losses, as in burn injuries.
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